This study, based on the TeO2 survey and a Tobit II model, analyzes regional disparities in the economic integration of immigrants in France. It distinguishes between large cities on one hand and intermediate and rural areas on the other. This study makes a twofold contribution. From an empirical perspective, it offers a systematic analysis of regional inequalities in the economic integration of immigrants in France, linking individual, institutional, and spatial dimensions. From a regional analysis perspective, it highlights the structuring role of local labor markets in the production of inequalities of opportunity and sheds light on the challenges of place-based integration policies, showing that the relevant levers for action differ significantly between metropolitan areas and peripheral territories. The results reveal a two-speed assimilation process: in cities, immigrants find it easier to access employment but suffer a lasting wage penalty; in peripheral areas, wage gaps are narrowing at the cost of lower participation. Differences based on origin, nationality, and length of stay remain significant: European immigrants are catching up with native-born workers, while those from North Africa, Africa, and Asia remain disadvantaged. Naturalization significantly improves employment and wages, acting as a signal of integration and institutional protection. These results call for differentiated policies: promoting skills in metropolitan areas and providing greater support in peripheral areas, with citizenship as an essential lever for economic equality.